https://wordpress.org/plugins/shareasale-wc-tracker/

Phytocannabinoids are naturally occurring cannabinoids found in the Cannabis sativa plant. They’re a class of chemical compounds that act on cannabinoid receptors and include endocannabinoids (produced in the bodies of all animals), phytocannabinoids (found in cannabis) and synthetic (man-made) cannabinoids.

Simply speaking, phytocannabinoids are the cannabinoids found in cannabis.

Of the 400 or so chemical compounds found in cannabis (it’s a very complex plant!), there are more than 60 phytocannabinoids that have been identified. Each has its own way of interacting with the body’s natural endocannabinoid system to elicit a variety of physiological effects.

Phytocannabinoids 101: An Introduction to Cannabis Cannabinoids

Hands down, the most famous phytocannabinoids are tetrahydrocannabinol (THC) and cannabidiol (CBD).

There are other phytocannabinoids, however, that have been discovered to play a fundamental role in the therapeutic benefits of the cannabis plant. A few of these include:

  • Cannabinol (CBN)
  • Cannabigerol (CBG)
  • Cannabichromene (CBC)

How Cannabinoids Work

Cannabinoids provide their therapeutic effects by emulating endocannabinoids that are naturally produced throughout the body that, when activated, help us maintain balanced health (think physical and psychological well-being).

Different cannabinoids bind to different receptor sites within the brain (CB1 receptors) and the body (CB2 receptors). The effects they produce are dependent upon the receptor they bind to. A product’s cannabinoid profile can offer insight on what kind of relief that particular product might offer.

Research indicates that the endocannabinoid system may serve as a bridge between the body and the brain, with the brain region a cannabinoid binds to responsible for various effects. These brain regions include several parts of the brain associated with pain perception, the limbic system (responsible for cognition, memory and psychomotor function) and the mesolimbic pathway (responsible for feelings of reward).

Let’s take a deeper look at the most common phytocannabinoids so we can better understand their therapeutic benefits and the way they interact with the endocannabinoid system.

5 Common Phytocannabinoids and Their Effects on the Endocannabinoid System

Cannabidiol (CBD)

CBD was first discovered in the 1940s, although research into the now wildly popular phytocannabinoid wouldn’t begin in earnest until around 2010, when cannabis samples that contained more CBD than THC began to be tested in earnest for the reported therapeutic benefits it contained.

CBD would go on to gain global attention a few years later when the story of Charlotte Figi (the young epileptic girl whose life was saved when CBD oil eradicated the hundreds of seizures she was experiencing on a daily basis) was featured on CNN.

Since then there has been countless research (both clinical and anecdotal) dedicated to CBD and its promising therapeutic effects.

How CBD Works

Unlike other cannabinoids, CBD doesn’t bind to CB1 or CB2 receptors. Instead, CBD works by enhancing and inhibiting particular protein-coupled receptors. These include:

  • Serotonin 1A Receptors (regulate metabolism and stress responses, affecting mood, cognition and appetite)
  • Vanilloid Receptors (play a role in pain perception, inflammation, and thermoregulation, or temperature regulation)
  • Nuclear Receptors (known as PPARs and influence an antiproliferative effect)
  • Orphan Receptors (known as GPR55 and is involved in regulating blood pressure, bone density and bone reabsorption)

CBD as an Anandamide Reuptake Inhibitor

CBD is also known to be an anandamide reuptake inhibitor, which helps to increase natural endocannabinoid levels in the brain. Anandamide (named after the Sanskrit word “bliss”) is a molecule that acts as a neurotransmitter, plays a role in several bodily functions and has a structure very similar to THC.

Anandamide is part of the endocannabinoid system and imbalanced levels of this important molecule have been associated with depression (low anandamide levels) and schizophrenia (high anandamide levels).

Tetrahydrocannabinol (THC)

THC was first discovered in the 1940s, but wasn’t synthesized and studied until 1964 by scientist Raphael Mechoulam at the Hebrew University of Jerusalem. Until increased research on CBD, THC was the most widely known phytocannabinoid and the one that received the most attention. It is, after all, what’s responsible for the psychoactive effects that made marijuana famous in the first place.

How THC Works

The “high” that THC is known for is caused by the activation of the CB1 cannabinoid receptor that is found in abundance throughout the brain. THC is what’s known as an agonist (or activator) of the CB1 receptor.

Research shows that when the CB1 receptor is blocked by a different drug known as an agonist, THC doesn’t elicit psychoactive effects. Because of this, it’s believed that the CB1 receptor is a critical component of the brain responsible for intoxication.

Some of the therapeutic effects of THC include relief from chronic pain, chemotherapy-induced nausea and vomiting, improving patient reported multiple sclerosis muscle spasticity symptoms and more.

Cannabigerol (CBG)

Like THC and CBD, cannabigerol (CBG) was discovered in the 1940s, but wouldn’t be studied more deeply for several decades.  Like CBD, CBG is a cannabinoid that doesn’t contain the psychoactive effects associated with THC.

Both CBD and THC start out as CBG — it can be thought of as the “parent” to these two highly beneficial cannabinoids. It starts out as cannabigerol acid (CBGA), the foundation for the three major cannabinoid lineages: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA).

Enzymes in the cannabis plant break down CBGA and it moves towards one of these specific lines. When the acids are exposed to heat or ultraviolet light, they are broken down into the cannabinoids THC, CBD, CBC.

How CBG Works

CBG has been shown to significantly stimulate GTP exchange binding to membranes of the brain and is thought to have a neuroprotective function. It binds to CB1 and CB2 receptors, although it has a higher affinity for CB1 than CB2 and is actually considered a CB1 antagonist rather than an agonist. CBG is also known to be an a2-adrenoceptor agonist, which provides a neuroprotective function.

Increased research on CBG shows that it has very specific therapeutic effects. Some of these include:

Cannabinol (CBN)

While discovered some time ago, research on CBN only began after CBD made headlines with its therapeutic effects. CBN is caused by the degradation of THC when prolonged exposure to air causes THC to lose hydrogen molecules and oxidize.

How CBN Works

In a 2012 study that looked at the effects of various cannabinoids on appetite, CBN was discovered to have an affinity for the CB1 receptor. Does this mean CBN gets you high? It’s currently believed that CBN doesn’t contain psychoactive effects, however, there are some psychoactive reports. The psychoactivity is extremely small compared to that of THC, though.

Research indicates that some of the therapeutic benefits of CBN include:

Cannabichromene (CBC)

While the phytocannabinoid cannabichromene was discovered back in the 60s, it hasn’t yet been studied in depth and more research is needed to better understand how it works with the endocannabinoid system. There is, however, some understanding of this cannabinoid that’s considered one of the “major” cannabinoids.

How CBC Works

CBC has a low binding affinity for CB1 receptors, which means it won’t produce any psychoactive effects. Like CBD, it binds to other receptors throughout the body, particularly the vanilloid receptor (TRPV1) and transient receptor potential ankyrin 1 (TRPA1). Both of these receptors are associated with the perception of pain.

Research shows that CBC could be beneficial for the following therapeutic applications:

Final Thoughts on Phytocannabinoids

The study of phytocannabinoids and their role in offering therapeutic benefits is still in its infancy. What is known, however, is that there are over 60 phytocannabinoids in the cannabis plant, and the ones that have been studied show promise for increased overall wellness.

Many of these phytocannabinoids are known to work together in a sort of interactive synergy that increases their overall effect, something known as the entourage effect. When we talk about full spectrum CBD, we’re essentially talking about the various cannabinoids working together using the full spectrum of compounds naturally present in cannabis.

Leave a Reply

Your email address will not be published. Required fields are marked *

Meet Joy Smith, Founder

Mom, Grandmother,
Philanthropist & CBD Entrepreneur.

Learn About Joy

Which CBD is Right For You?


Take a quick quiz to find out

Step 1: Organic Farming

Learn more About Joy's
100% Organic Process

Our Process

All Natural Goodness

Premium Grade Hemp Oil / Made in USA

Shop Products

Our Store

Come Visit Joy's Store in Fort Collins. CO

Visit Us

Joy's friends get updates on new products and special coupons!

  • This field is for validation purposes and should be left unchanged.

What Our Clients Say.

Rating:

"My caretaker can hardly believe what she sees in my mobility. I have not slowed down. Every day since taking the softgels I have been walking without arthritic pain. It indeed is like a miracle."
- Don

  • Wholesale Partner FAQ’s:

    DO YOU PROVIDE EXPRESS DELIVERY?
    Yes. Just select your desired shipping method during checkout. There is an extra charge for express shipping.

    HOW QUICKLY ARE WHOLESALE ORDERS SHIPPED?
    All orders received by 12 PM MST Monday-Friday are shipped same day. Orders placed after 12PM MST or on the weekend will ship on the next business day.

    CAN YOU SHIP TO P.O. BOXES?
    Yes.

    CAN YOU SHIP OUTSIDE THE U.S.?
    No. We are currently only shipping within the US.

    I LIVE CLOSE TO YOUR STORE. CAN I PICK UP MY ORDER?
    We do not provide order fulfillment from our store, but if you are in a jam and need some products quickly, send an email to [email protected] and we will do everything we can to help you.

    WHAT IS YOUR RETURN POLICY ON WHOLESALE ORDERS?
    We offer a 30 day return period on all orders.

    WHAT IS ONE OF MY CUSTOMERS RETURNS ONE OF THE PRODUCTS?
    Please give your customer a full refund, then email us at [email protected] and we will send you a replacement at no charge.

    HOW DO I BECOME KNOWLEDGEABLE IN SELLING YOUR CBD PRODUCTS TO MY CUSTOMERS?
    Read our website and Ultimate CBD Guide. You can also check out product videos posted by Todd Smith (Joy’s husband) here.

    DO YOU HAVE BROCHURES?
    Yes. We will include one of our full-color tri-fold brochures for each product purchased. Order 50 products and you will get 50 brochures. Additional brochures are available for purchase.

    DO I NEED A SPECIAL LICENSE TO SELL HEMP OIL PRODUCTS?
    We are not aware of any city, county or state that requires a special license to sell our THC-free hemp oil products.

    WHAT DO YOU REQUIRE FROM THE RETAILERS WHO SELL YOUR PRODCUTS?
    You will need to sign our Wholesale Reseller Agreement.

    DO YOU OFFER TAX-EXEMPT ORDERS?
    Yes. Please provide us with a copy of your Tax Exempt Certificate for your state.

    WHAT WOULD CAUSE YOU TO TERMINATE A RELATIONSHIP WITH A WHOLESALE PARTNER?
    As long as you are operating with integrity, representing the Joy Organics brand with class and not making medical claims, we will have a great relationship.

    CAN YOU HELP ME SET UP MY WEBSITE?
    Yes. We have a third party team that can help you design and build your website.

    DO YOU HAVE ANY PRODUCT PHOTOS I CAN USE FOR MY WEBSITE/MARKETING?
    We have a great photo file that is updated weekly with product visualizations, lifestyle photos, and many more!

    CAN WE USE THE MATERIAL ON YOUR WEBSITE?
    You are free to use any material listed on our website. We recommend rewording content so that you do not get flagged by Google.

    DO YOU OFFER DROP SHIPPING?
    Yes. Ask our wholesale team about the details of our Drop Shipping program.

    WHAT IS YOUR SUGGESTED RETAIL VALUE?
    As a wholesale partner, you are required to offer our products at retail value as listed on our site. You may up prices if you would like.

    CAN I SELL YOUR PRODUCTS ON AMAZON, EBAY, ETSY, OR OTHER SALE SITES?
    No. We do not allow Joy Organics to be sold on any sales site. If you would like to sell our products online, your site must be approved by our team prior to purchasing.

    DO YOU OFFER ANY SAMPLES TO OFFER MY CUSTOMERS?
    Yes. Salve, softgels, and skin care samples that are available to purchase. We are currently working on samples for the rest of our products as well.

    CAN I CLAIM A TERRITORY?
    No. We do not promise territories to our partners.

    DO YOU HAVE A MERCHANT PROCESSOR I CAN USE?
    Yes. We can introduce you to a great team that will help you set up your merchant processor.

    WHO SHOULD I OPEN A BANKING ACCOUNT WITH?
    Speak with one of our team members today to discuss which bank would be best for you.

    DO I NEED TO OFFER A LIABILITY INSURANCE BY SELLING YOUR PRODUCTS?
    We recommend keeping insurance in case of theft or an accident, but as long as you do not tamper with any of the products, you do not need to carry liability insurance.

    DO YOU OFFER A NON-COMPETE CLAUSE?
    No.

    CAN I OFFER MY OWN PROMOTIONS?
    You are able to offer set promotions as outlined in the Wholesale Reseller Agreement if you have a store location. E-Commerce sites cannot offer promotions.

    I FEEL AS THOUGH I WILL BE COMPETING WITH YOUR ONLINE STORE. WHAT ARE YOU DOING ABOUT THIS?
    We have found that 90% of customers will not switch to a different retailer just because of the brand name. We recommend building a solid relationship with your customers. If you own a store where customers can come in the learn about Joy Organics, we will add you to our City Pages. This is a great way Joy Organics can help with your marketing efforts and send business your way!

    DCAN I ALSO SIGN UP FOR THE AFFILIATE PROGRAM?
    Yes! In fact, we recommend it. All active wholesale partners are automatically approved to become affiliates.

    WHAT IS THE STORAGE LIFE OF YOUR PRODUCTS?
    We guarantee potent products for up to 18 months.

    DO YOU SELL BULK CBD?
    Yes. Please reach out to our team to connect to our bulk department.

    WHAT ARE YOUR BEST SELLERS?
    Contact one of our team members to find out which products are selling best right now!

  • OUR UNIQUE PROCESS

    Joy’s processes ensure that her products provide an effective solution while remaining at an affordable price point.

    Each of our hemp oil droplets is between 4 to 200 times smaller than the industry standard. This means that they’re more easily absorbed into the blood whether consumed orally or applied to the skin.

    Our solution was to create a water-soluble nanoemulsion technology. This patent-pending technology transforms active compounds into nano-sized emulsions.

    Our highly bioavailable products are not only extremely effective, they’re also extremely economical. You’ll get the same results from a much smaller amount of what we create than you would from our competitors. This is better for you and your wallet.

  • JOY’S STORY

    Joy is a wife, mom and grandmother. As a self-proclaimed “health nut”, her story begins in a place that many of us know very well – persistent pain and trouble sleeping.

    While researching natural solutions, Joy learned of the benefits of CBD and began trying the top brands.

    What she found was distressing: only one of the seven biggest CBD oil brands gave her the relief she desired.

    After more research, the answer became obvious. Today’s CBD oil industry is a mess. There is minimal government oversight. No enforcement of false label claims and a huge variety of ineffective extraction and delivery methods.

    As Joy’s frustration grew, so did her passion for creating a product people could trust. She then put together her team to create the most pure, organic, and bioavailable THC-free full spectrum hemp oil on the market.

  • 12 BENEFITS OF JOY

    Zero THC – THC is the psychoactive compound in Marijuana
    Free Shipping – Complimentary shipping anywhere in the US.
    No Risk – All products come with a 30 day money back guarantee.
    High Absorption – Our softgels are 4x more absorbable than a standard tincture oil.
    World-Class Customer Support – Here for you to make sure your questions are answered!
    USA Proud – All products are organically grown, processed and manufactured in the USA.
    Full Spectrum – All products include all of the cannabinoids present in the hemp plant.
    Pharmaceutical Grade – Our products considered pharmaceutical grade because they are manufactured in a GMP certified facility by the FDA.
    Consistency – All our hemp oil comes from the exact same extraction process in the same facility, which ensures consistency.
    Every Batch is Tested – Each batch is tested to ensure the highest quality hemp oil available without any metals, pesticides or THC.
    Chromatography Process – Only company in the world with the chromatography process which removes THC, waxes and chlorophyll and leaves all the cannabinoids, terpenes and flavonoids
    Family Owned & Operated – Our company owned and managed by Joy’s family.
    Veteran Friendly – All three of Joy’s brother’s served in the US military.

  • {"cart_token":"","hash":"","cart_data":""}