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We’re fascinated with the way phytocannabinoids work in harmony with the body’s own endocannabinoid system. One of the most popular reasons people report using CBD is the positive effect it can have on anxiety.

Why do naturally occurring cannabinoids such as CBD, THC and others seem to help alleviate anxiety?

In essence, it all comes down to the endocannabinoid system which, among other things, is largely associated with our mood and emotional states.

The Endocannabinoid System and Anxiety

In one of our favorite studies about cannabidiol as a potential relief for anxiety disorders, researchers found existing preclinical evidence that strongly supports using CBD for several anxiety-related disorders including:

  • Generalized anxiety disorder
  • Panic disorder
  • Social anxiety disorder
  • Obsessive-compulsive disorder
  • Post-traumatic stress disorder

Because the study found that “overall, current evidence indicates that CBD has considerable potential as a treatment for multiple anxiety disorders” and that CBD works in harmony with the endocannabinoid system, we wanted a better understanding of the connection between the endocannabinoid system and anxiety in general.

Here’s what we discovered.

According to research, the endocannabinoid system is a signaling system within the brain that acts to control neurotransmitter release. The expression of the endocannabinoid system in the limbic regions of the brain causes it to have control over emotional behavior, mood and stress response.

Research shows that a “growing body of evidence unequivocally demonstrates” that disruptions in endocannabinoid signaling could result in depressive and anxious behavioral responses. It also suggests that manipulating endocannabinoid signaling can cause an anxiolytic response.

How does it work?

What exactly is the connection between the endocannabinoid system and anxiety?

To understand this, it’s vital to better understand the endocannabinoid system itself.

A Brief Overview of the Endocannabinoid System

The endocannabinoid system has been referred to as one of the body’s most important physiological systems. Basically, it’s responsible for pretty much everything involved with our physical and emotional health. Sleep, mood, pain, digestion, immune response and more…it all comes down to the endocannabinoid system.

There are two main endocannabinoids that have been identified in the human body: anandamide and 2-Archidonoylgycerol (2-AG).

The primary receptor sites in the endocannabinoid system are known as the CB1 (found in the central nervous system) and CB2 receptors (found in the immune system and almost everywhere outside the brain and spinal cord).

Anandamide, named after the Sanskrit word for bliss because of the feelings of happiness it produces, is a neurotransmitter that forms part of a neurochemical system that helps regulate mood (as well as pain and appetite).

It should come as no surprise, then, to learn that our mood, happiness levels, anxiety, fear and ability to endure stress are all controlled by the endocannabinoid system. When anandamide levels are imbalanced, anxiety will almost assuredly ensue.

In the brain, anandamide is broken down by the enzyme fatty acid amide hydrolase (FAAH). Research suggests that those with increased levels of happiness (think less anxiety) simply have more levels of the endocannabinoid anandamide in their system.

Research shows that anandamide deficiency predicts stress-induced anxiety and suggests that the reversal of stress-induced anandamide deficiency is a key component in the therapeutic effects of FAAH inhibition.

The Endocannabinoid System as a Regulator of General Anxiety

When it comes to managing anxiety, it’s well-known that several different neurotransmitter systems are involved. This, combined with the function of CB1 receptors in the suppression of neurotransmitter release, is why the endocannabinoid system can be regarded as one of the primary regulators of anxious behavior.

In a 2005 review, authors suggested that the mediating effects of cannabinoids (such as CBD) on anxiety-related responses appear to involve both CB1 and non-CB1 cannabinoid receptors. It’s been discovered that brain regions such as the amygdala, cortex and hippocampus (all of which are involved in emotional behavior) are teeming with CB1 receptors.

Research shows that in animal studies where mice are lacking CB1 receptors, they often show anxiety and depressive-like symptoms, as well as significant alterations in their stress response. It was discovered that blocking CB1 receptors in mice induces anxiety, while the inhibition of anandamide metabolism leads to an anti-anxiety effect.

This is something that led researchers to suggest that the endocannabinoid system appears to play an essential role in one’s emotional state and could be a powerful target used in anti-anxiety therapy.

Endocannabinoid Deficiency and Anxiety

Endocannabinoid deficiency syndrome was first proposed in 2004 by Dr. Ethan Russo, neuroscientist and renowned cannabinoid expert. In a groundbreaking study, Russo suggested a deficiency in the body’s natural endocannabinoid levels could be the reason behind some conditions.

Further research indicates that deficiencies in natural cannabinoids could result in a predisposition to developing PTSD and depression. Authors of the study note that there is “evidence the ECS serves in an anxiolytic, and possibly anti-depressant, role.”

The Endocannabinoid System and Anxiety Related to PTSD

Post-traumatic stress disorder (PTSD) can manifest after a particularly disturbing and traumatic event that reaches far beyond typical stressors that can lead to anxiety. Things that might lead to PTSD include things such as violent personal assault, combat, accidents, natural disasters and more.

While at least half of all adults will experience a traumatic event at some point in their lifetime, not everyone will develop PTSD. Those who do, however, may experience persistent thoughts or memories of the event, might startle easily, could experience sleep problems and feel detached or numb. People with severe forms of PTSD can experience significant problems in their personal lives on a multitude of levels.

What does PTSD have to do with the endocannabinoid system?

A 2013 study was the first to discover that individuals with PTSD have significantly lower concentrations of anandamide than people without PTSD.

For the study, researchers divided 60 individuals into three groups: people with PTSD, people with a history of trauma but no PTSD and people with no history of trauma or PTSD.

Brain imaging detected that individuals with PTSD (especially women) had more CB1 receptors in brain regions associated with fear and anxiety than those without PTSD. It was also discovered that they had lower levels of anandamide, which actually binds to CB1 receptors.

According to the study’s author, when anandamide levels become too low, the brain compensates by increasing the number of CB1 receptors, which “helps the brain utilize the remaining cannabinoids.”

Understanding that those who suffer from PTSD could have lower levels of anandamide, it makes sense that CBD has shown to help with PTSD-related anxiety as the non-psychoactive cannabinoid could work as a sort of anandamide replacement, as the two share extremely comparable structural and chemical characteristics.

Research also suggests that endocannabinoid system signaling promotes both the extinction of fear memories and conditioned fear responses, both hallmark characteristics of PTSD-related anxiety.

The Endocannabinoid System and the Fight or Flight Response

Most everyone is familiar with times of considerable stress or when experiencing a stressful event makes us shift into fight or flight mode. “Fight or flight” is also known as the acute stress response and refers to a very real physiological reaction that occurs when a stressful event happens.

The flight or fight response plays a huge role in how we react to stress and danger in our environment. It can be super helpful in some situations because the stress may help us better deal with the threat we’re facing.

Here’s the thing, though. Some people experience feelings of fight or flight when there isn’t any danger. And in cases such as these, anxiety is a large part of the flight or fight response.

It’s been discovered that CBD may help reduce the negative influence of fight or flight through the activation of the adenosine receptor in the endocannabinoid system. Much like CB1 receptors, adenosine receptors are primarily found in the brain and spinal cord.

When adenosine levels are stimulated, there is also a rise in dopamine and glutamate neurotransmitter levels. Dopamine is responsible for perception, motivation and reward, while glutamate is responsible for cognition, learning and memory.

While more research is warranted, it’s suggested that the endocannabinoid system and the interaction and effect it has with adenosine receptors has a significant influence on feelings of fight or flight.

As CBD Popularity Grows, So Will ECS Research

The increasing popularity of CBD and other cannabinoids has led to increased understanding of how these cannabis compounds work in harmony with our bodies. The discovery of the endocannabinoid system has opened the door for a wealth of information on why cannabinoids contain the positive effects they do.

There are numerous studies that show the potential benefits of cannabinoids for the mitigation of anxiety and anxiety-related disorders. Research shows that the endocannabinoid system seems to have a large influence on anxiety, giving us a deeper understanding of not only the potential of cannabinoid therapy but also of anxiety itself.

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"Joy Organics products have really positively impacted my life. I am very careful what type of products I use on my body and for my health, and after days of research, I found Joy Organics. Not only are their products made from high-quality ingredients, but their customer service and genuine interest in the well being of their customers is on another level. This company goes above and beyond for its customers 😀 I wish this company nothing but success, because you all deserve it!"
- Robert

  • Testimonials:

    “I have really enjoyed dealing with the service department at Joy Organics, there has never been a time that I have called that someone didn’t call or message me back immediately. When you have a business and you deal with other companies it’s always a good feeling knowing no matter what question you ask, to know you will get a in-depth answer. I love this about Joy Organics. They are always on point!”

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    “Wonderful Group to work with. Everything from fantastic products, prices, customer support, beautiful packaging to fast, friendly service. Joy Organics is family and feels like family! And why it is included in my line of ‘Paulines Preferred’.”

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    “People on CBD related FB pages have messaged me asking what company I decided to go with. Of course I tell them Joy Organics! We all had miserable experiences that ranged from not receiving all items ordered to lackluster customer service. I couldn’t take it any longer so I did a Google search and that’s when I came across Todd’s videos on YouTube. I was totally blown away by his honesty on what to look for in a CBD supplier and the obstacles to watch out for along the way. Most importantly, how to get approved for a merchant account! Not to mention the customer is always right philosophy. Becca and Alyx are prompt to answer any emails. I couldn’t ask for a better support team and that’s why I will continue doing business with Joy Organics.”

    -Robin Hood / Lone Star Organic

     

    “Joy Organics is an all around class-act!! They are always cheerfully willing to answer any of my questions, and are always prompt in shipping their premium CBD products! I am sincerely honored to be part of this caring, top-notch team of professionals!”

    -Sonja Broderick / Apache Junction

     

    “I am a wholesale partner with Joy Organics and am so pleased to be in partnership with such a wonderful company and caring group of people. The knowledge that is encompassed within this group of people for their product is amazing to me. I am learning on a daily basis as they are constantly sharing their knowledge with us. Someone is always available to answer questions. The turn around time from order to delivery of Joy Organics is incredibly fast, accurate,and nicely packaged. If you are looking to partner up in a wholesale capacity with a professional and caring business,look no further. You found it!”

    -Venus Warner

     

    “In early November 2018 we decided to start looking for a supplier to add to our Specialty Food Store CBD products. We as most people do now Google Organic CBD and we found number of suppliers. Next, we contact some of them and when we contacted Joy Organic after reviewing their webpage, we know we had found the supplier for our store. We pride ourselves on our customer experience. We found the same type of experience for Joy Organic. We have been providing some of there products to our guests with overwhelming ratification.”

    -Richard Morgan / The Tree of Oil LLC

  • Wholesale Partner FAQ’s:

    DO YOU PROVIDE EXPRESS DELIVERY?
    Yes. Just select your desired shipping method during checkout. There is an extra charge for express shipping.

    HOW QUICKLY ARE WHOLESALE ORDERS SHIPPED?
    All orders received by 12 PM MST Monday-Friday are shipped same day. Orders placed after 12PM MST or on the weekend will ship on the next business day.

    CAN YOU SHIP TO P.O. BOXES?
    Yes.

    CAN YOU SHIP OUTSIDE THE U.S.?
    No. We are currently only shipping within the US.

    I LIVE CLOSE TO YOUR STORE. CAN I PICK UP MY ORDER?
    We do not provide order fulfillment from our store, but if you are in a jam and need some products quickly, send an email to wholesale@joyorganics.com and we will do everything we can to help you.

    WHAT IS YOUR RETURN POLICY ON WHOLESALE ORDERS?
    We offer a 30 day return period on all orders.

    WHAT IS ONE OF MY CUSTOMERS RETURNS ONE OF THE PRODUCTS?
    Please give your customer a full refund, then email us at wholesale@joyorganics.com and we will send you a replacement at no charge.

    HOW DO I BECOME KNOWLEDGEABLE IN SELLING YOUR CBD PRODUCTS TO MY CUSTOMERS?
    Read our website and Ultimate CBD Guide. You can also check out product videos posted by Todd Smith (Joy’s husband) here.

    DO YOU HAVE BROCHURES?
    Yes. We will include one of our full-color tri-fold brochures for each product purchased. Order 50 products and you will get 50 brochures. Additional brochures are available for purchase.

    DO I NEED A SPECIAL LICENSE TO SELL HEMP OIL PRODUCTS?
    We are not aware of any city, county or state that requires a special license to sell our THC-free hemp oil products.

    WHAT DO YOU REQUIRE FROM THE RETAILERS WHO SELL YOUR PRODCUTS?
    You will need to sign our Wholesale Reseller Agreement.

    DO YOU OFFER TAX-EXEMPT ORDERS?
    Yes. Please provide us with a copy of your Tax Exempt Certificate for your state.

    WHAT WOULD CAUSE YOU TO TERMINATE A RELATIONSHIP WITH A WHOLESALE PARTNER?
    As long as you are operating with integrity, representing the Joy Organics brand with class and not making medical claims, we will have a great relationship.

    CAN YOU HELP ME SET UP MY WEBSITE?
    Yes. We have a third party team that can help you design and build your website.

    DO YOU HAVE ANY PRODUCT PHOTOS I CAN USE FOR MY WEBSITE/MARKETING?
    We have a great photo file that is updated weekly with product visualizations, lifestyle photos, and many more!

    CAN WE USE THE MATERIAL ON YOUR WEBSITE?
    You are free to use any material listed on our website. We recommend rewording content so that you do not get flagged by Google.

    DO YOU OFFER DROP SHIPPING?
    Yes. Ask our wholesale team about the details of our Drop Shipping program.

    WHAT IS YOUR SUGGESTED RETAIL VALUE?
    As a wholesale partner, you are required to offer our products at retail value as listed on our site. You may up prices if you would like.

    CAN I SELL YOUR PRODUCTS ON AMAZON, EBAY, ETSY, OR OTHER SALE SITES?
    No. We do not allow Joy Organics to be sold on any sales site. If you would like to sell our products online, your site must be approved by our team prior to purchasing.

    DO YOU OFFER ANY SAMPLES TO OFFER MY CUSTOMERS?
    Yes. Salve, softgels, and skin care samples that are available to purchase. We are currently working on samples for the rest of our products as well.

    CAN I CLAIM A TERRITORY?
    No. We do not promise territories to our partners.

    DO YOU HAVE A MERCHANT PROCESSOR I CAN USE?
    Yes. We can introduce you to a great team that will help you set up your merchant processor.

    WHO SHOULD I OPEN A BANKING ACCOUNT WITH?
    Speak with one of our team members today to discuss which bank would be best for you.

    DO I NEED TO OFFER A LIABILITY INSURANCE BY SELLING YOUR PRODUCTS?
    We recommend keeping insurance in case of theft or an accident, but as long as you do not tamper with any of the products, you do not need to carry liability insurance.

    DO YOU OFFER A NON-COMPETE CLAUSE?
    No.

    CAN I OFFER MY OWN PROMOTIONS?
    You are able to offer set promotions as outlined in the Wholesale Reseller Agreement if you have a store location. E-Commerce sites cannot offer promotions.

    I FEEL AS THOUGH I WILL BE COMPETING WITH YOUR ONLINE STORE. WHAT ARE YOU DOING ABOUT THIS?
    We have found that 90% of customers will not switch to a different retailer just because of the brand name. We recommend building a solid relationship with your customers. If you own a store where customers can come in the learn about Joy Organics, we will add you to our City Pages. This is a great way Joy Organics can help with your marketing efforts and send business your way!

    DCAN I ALSO SIGN UP FOR THE AFFILIATE PROGRAM?
    Yes! In fact, we recommend it. All active wholesale partners are automatically approved to become affiliates.

    WHAT IS THE STORAGE LIFE OF YOUR PRODUCTS?
    We guarantee potent products for up to 18 months.

    DO YOU SELL BULK CBD?
    Yes. Please reach out to our team to connect to our bulk department.

    WHAT ARE YOUR BEST SELLERS?
    Contact one of our team members to find out which products are selling best right now!

  • OUR UNIQUE PROCESS

    Joy’s processes ensure that her products provide an effective solution while remaining at an affordable price point.

    Each of our hemp oil droplets is between 4 to 200 times smaller than the industry standard. This means that they’re more easily absorbed into the blood whether consumed orally or applied to the skin.

    Our solution was to create a water-soluble nanoemulsion technology. This patent-pending technology transforms active compounds into nano-sized emulsions.

    Our highly bioavailable products are not only extremely effective, they’re also extremely economical. You’ll get the same results from a much smaller amount of what we create than you would from our competitors. This is better for you and your wallet.

  • JOY’S STORY

    Joy is a wife, mom and grandmother. As a self-proclaimed “health nut”, her story begins in a place that many of us know very well – persistent pain and trouble sleeping.

    While researching natural solutions, Joy learned of the benefits of CBD and began trying the top brands.

    What she found was distressing: only one of the seven biggest CBD oil brands gave her the relief she desired.

    After more research, the answer became obvious. Today’s CBD oil industry is a mess. There is minimal government oversight. No enforcement of false label claims and a huge variety of ineffective extraction and delivery methods.

    As Joy’s frustration grew, so did her passion for creating a product people could trust. She then put together her team to create the most pure, organic, and bioavailable THC-free full spectrum hemp oil on the market.

  • 12 BENEFITS OF JOY

    Zero THC – THC is the psychoactive compound in Marijuana
    Free Shipping – Complimentary shipping anywhere in the US.
    No Risk – All products come with a 30 day money back guarantee.
    High Absorption – Our softgels are 4x more absorbable than a standard tincture oil.
    World-Class Customer Support – Here for you to make sure your questions are answered!
    USA Proud – All products are organically grown, processed and manufactured in the USA.
    Full Spectrum – All products include all of the cannabinoids present in the hemp plant.
    Pharmaceutical Grade – Our products considered pharmaceutical grade because they are manufactured in a GMP certified facility by the FDA.
    Consistency – All our hemp oil comes from the exact same extraction process in the same facility, which ensures consistency.
    Every Batch is Tested – Each batch is tested to ensure the highest quality hemp oil available without any metals, pesticides or THC.
    Chromatography Process – Only company in the world with the chromatography process which removes THC, waxes and chlorophyll and leaves all the cannabinoids, terpenes and flavonoids
    Family Owned & Operated – Our company owned and managed by Joy’s family.
    Veteran Friendly – All three of Joy’s brother’s served in the US military.

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